3. Oral/ODT Meds - Needs work

• Acetaminophen Class


  Non-opioid analgesic, Antipyretic
• Acetaminophen MOA


  Antipyretic

  • Inhibits formation & release of prostaglandins in the CNS

  • Inhibits pyrogens at the hypothalamic thermoregulatory center

  
  

  Analgesia

  • The exact MOA is unknown - may be due to its inhibition of CNS prostaglandin synthesis and elevation of pain threshold
• Acetaminophen Indications


  - Tx of fever

  - Tx of minor non-inflammatory conditions in pts prone to gastric damage
• Acetaminophen Contraindications


  - Known Sensitivity

  - Active & severe hepatic disease/impairment

  - Unable to control airway or chew/swallow
• Acetaminophen SE

  - Hepatotoxicity with OD/misuse

  - Gastric irritation - N/V, Abdominal pain

  - Unpleasant taste
• Acetaminophen Adult Dose


  650mg q4-6 hrs

  Max: 4 dose/24 hrs
• Acetaminophen Infant/Children <60kg Dose


  15mg/kg q4-6 hrs

  Max: 650mg
• Aspirin Class


  Platelet aggregation inhibitor

  NSAID
• Aspirin MOA


  Anti-platelet - prevents thromboxane A2 formation
• Aspirin Indications


  - Chest pain/discomfort - suggestive ACS

  - Analgesia - tx minor arthritic pain

  - Antipyretic - fever
• Aspirin Contraindications


  - Known sensitivity to ASA/NSAIDS

  - Significant renal impairment

  - Unable to control airway, chew/swallow
• Aspirin SE


  - Kidney/Liver issues/failure

  - Gastric upset/bleeding

  - Tinnitus
• Aspirin Adult Dose


  200-400mg q6 hrs

  Max 1200mg/day
• Aspirin Ped 6-12 y/o Dose

  5-10mg/kg PO q6-8 hrs

  Max 600mg
• Ondansetron HCl Class

  Selective Serotonin Receptor (5-Ht3) antagonist

  Anti-emetic
• Ondansetron HCl MOA


  Blocks action of serotonin - natural substance that causes N/V
• Ondansetron HCl Indications


  Prevention/Control of N/V
• Ondansetron HCl Contraindications


  - Known Sensitivity

  - Known long QT syndrome
• Ondansetron HCl SE


  - HA

  - Malaise

  - Cardiac dysrhythmias (bradycardia, SVT, VT)

  - QT interval prolongation
• Ondansetron HCl Adult Dose


  4mg IV/IO/IM/SL/ODT

  May repeat 1x in 10 min
• Ondansetron HCl Ped 6m-14y Dose


  0.15 mg/kg IV/ODT

  Max 4mg