Female Reproductive System & Breast Ia

• Sclerosing adenosis is marked proliferation of luminal spaces & fibrous stroma
• Non-proliferating changes are characterised by cystic dilation of ducts & interstitial fibrosis
• Intra - ductal papilloma is a benign neoplastic papillary growth in ductals
• Phyllodes tumour is a neoplastic stromal cells & epithelium - lined glands forming leaf - like projections
• Fibroadenoma is characterised by loose fibroblastic stroma containing duct-like, epithelium - lined spaces of various shapes & size with no invasion of the BM
• HER2 / NEU proto-oncogene is over expressed in breast cancer
• Luminal B subtype is characterised by ER (+), PR (-) & HER2/NEU (+)
• Colloid Carcinoma is associated with positive ER & PR & no over expression of HER/NEU
• Invasive ductal Carcinoma has a heterogeneous appearance