Refers to the extent to which two (or more) conditions can co-occur; if they occur together frequently the validity is questioned. SCZ is commonly diagnosed with other conditions; Buckley et al estimates co-morbid depression occurs in 50% of patients, 47% had co-morbid substance abuse, 29% with PTSD. If depression occurred with half, in terms of diagnosis, it may be that we cannot tell the difference. In terms of classification, they may be seen as a single condition instead (SCZ may be severe depression).