Decreased vasodilation & permeability of capillaries,
Decreased leukocyte migration to sites of inflammation
Bind to glucocorticoid receptor → mediated changes in gene expression → multiple downstream effects (over hours to days)
Inhibit neutrophil apoptosis & demargination
Inhibit phospholipase A2 → decreases formation of arachidonic acid derivatives → inhibit NF-kappa B & other inflammatory transcription factors & promote anti-inflammatory genes (e.g. IL-10)
Low dose → anti-inflammatory effect
High dose → immunosuppressive
