1.1

• Secondary Hemostasis


  Formation of irreversible clot (Fibrin)
• Coagulable cascade


  Coagulation Pathway and Coagulation Factors
• Coagulation pathways and Activators

  1. Extrinsic: Activated by tissue thromboplastin

  2. Intrinsic: Activated by Collagen

  3. Common: both intrinsic and extrinsic by formation of prothrombinase complex
• Coagulation factors


  • Synthesize in Liver except III and IV
  • Circulating in inactive/zymogen form except III and IV
  • All coagulation factors including PK and HMWK, active forms are in Serine Proteases except:
  • Factor 1 (Fibrinogen): main substrate
  • Factor V and VIII: as cofactors
  • Factor XIII (Transglutaminase/Transaminase): for fibrin plug stabilization
• COAGULATION FACTORS


  • Numeral
  • Preferred name
  • Synonyms
  • Genetic disorders and other infos
• Fibrinogen is associated with Congenital Afibrinogenemia/Hypofibrinogenemia/Dysfribrinogenemia, Familial renal Amyloidosis, NV: 200-400 mg/dL, Inc PT & APTT: <80 mg/dL
• Prothrombin is associated with Prothrombin deficiency, Thrombophilia
• Tissue Factor is present in tissues and are insoluble
• Calcium is a labile factor
• Proaccelerin is associated with Owrensen’s disease, Leiden dse, Parahemophilia, Activated protein C Resistant
• Proconvertin is associated with Congenital Factor VII deficiency, Hemopilia, 1st to be affected by Warfarin
• Antihemophilic Factor VIII is associated with Hemophilia A, Classic Hemophilia, Royals Disease, VWF: largest and heaviest mol in plasma
• Plasma Thromboplastin Component IX is associated with Hemophilia B, Christmas Factor Dse
• Stuart-Prower Factor X is associated with Congenital Factor X, Stuart Power disease
• Plasma Thromboplastin Antecedent XI is associated with Hemophilia C, Rosenthal syndrome, 50% hemophilia seen in Askenazi Jews
• Hageman Factor XII is associated with Hereditary angioedema type II, NO BLEEDING TENDANCY
• Fibrin-Stabilizing Factor XIII is associated with Congenital Factor XIII deficiency, Associated with POOR HEALING
• Prekalikrein (PK) is associated with Kininogen deficiency
• High Molecular Weight Kininogen is associated with Kininogen deficiency