Quiz2nd

• Mirror image chromosome and loss one arm with duplication of other?

  Isochromosome
• This results from chromosome breakage with subsequent re-union in a different configuration. THEY CAN BE BALANCED OR UNBALANCED?

  Structure chromosome Rearrangements
• Changes to number of chromosomes present, are referred to as aneuploidies?

  Numerical
• What are the types of chromosomal abnormalities?

  Numerical and structural abnormalities
• Numerical abnormalities?

  Aneuploidy and polyploidy
• Amount of genetic information in the chromosome can change?

  Deletion and Duplication
• The genetic material remains the same but it is rearrange?

  Inversion and Translocation
• What are the 2 types of deletion?

  Terminal and Interstitial
• What is aneuploidy?

  Refers to cytogenetic abnormalities in which all or part of one or more chromosomes is added or deleted
• What is non-disjunction?

  It is when paired chromosomes failed to separate during meiosis I or meiosis II
• What is Autosomal Aneuploidy?

  Refers to all such abnormalities that do not involve sex chromosomes
• What is chromosomal aberration?

  It is the substantial change in chromosome structure
• Occurs during life?

  Acquired Chromosome abnormalities
• This is present from birth or occurs de novo?

  Constitutional Chromosomal Rearrangements
• What is Polyploidy?

  A condition in which the cells have more than 2 non-homologous sets of chromosomes
• What is Chromosome Abnormalities?

  A disorder characterized by morphological or numerical alterations in single or multiple chromosomes