A study by Hare et al looked at DNA 112 MtF( male to female) transsexuals and found they were more likely to have longer version of version of the androgen receptor gene than in a normal sample – the effect of this abnormality is the reduced action of the male sex hormone , testosterone and this may have an effect on gender development in the womb which explains the study’s findings – could cause an under- masculinising in the brain