An infected mosquito, acting as a vector, bites a human. Plasmodium enters the human bloodstream. Asexual reproduction occurs in the liver and then in the red blood cells. When the red blood cells burst gametocytes are released into the bloodstream. Another mosquito bites an infected human and the gametocytes enter the mosquito, maturing into male and female gametes, allowing sexual reproduction to now occur. The mosquito can then infect another human host.