Results:

• Amphetamine had minimal effect on regional cerebral blood flow when participants completed both tasks.
• No significant differences in the effects of amphetamines and the placebo on brain activity when completing the BAR. Some significant difference in blood flow in particular region of the brain when completing the ECST. The left dorsolateral prefrontal cortex, the occipital and anterior cingulate cortices were all affected.
• Amphetamines had a small but significant positive effect on two performance measures of the WCST, including the number of correct responses. There was no such effect when the placebo was used.
• Behaviour changes caused by the amphetamine were highly variable and generally mild, ranging from increased cooperation, optimism and improved mood to irritability and dysphoria. Three patients showed clinically significant improvement whereas one patient significantly deteriorated