Research is limited by always thinking of endogenous pacemakers and exogenous zeitgebers as separate. Perhaps their effects should be thought of as combined and studied holistically
The opposing theory is the holistic theory which instead states that all parts of the brain are involved and work together in processing thoughts and actions
Plasticity provides an argument against localisation, as equipotentiality takes place in patients that have been subject to brain injury, where the brain reorganises itself after damage to recover lost function in a different part of the brain