Laurice Guillen studied at St. Theresa's College, Cebu City, earned an AB English degree before finishing an MA in Communication at Ateneo de Manila University, followed by a television production course under Nestor Torre, in 1967. She then began work as an actress, starring in productions of Mrs. Warren's Profession, before crossing over to film and television work, playing a seductress in Tinimbang Ka Ngunit Kulang, and Corazon Aquino in the drama A Dangerous Life. In 2009 she accepted a role in the indie film Karera, her first role in an independent production. Other credits include in the film Sister Stella L and Moral. However, it was on television that she became a household name when she joined the cast of "Flor de Luna" in 1978 as Jo Alicante, Flor de Luna's temperamental step mother. She went on to portray the role until the mid-80s when the show folded