Loading dose administration
1. For adults with normal renal function, usual approach is total loading dose of approximately 10 mcg/kg based on ideal body weight
2. Approximately 50% of total load given as first dose, followed by 25% at 6-8 hour intervals orally or IV
3. Loading carried out over 24 hours with 3-4 divided doses
4. Onset of effect and negative side effects determined by rate of distribution to site of action (1-4 hours for IV, 2-6 hours for oral)