Module 1.0

• what is pharmaceutics?

  • formulation of a drug (API) to a safe and effective drug delivery system
• according to aulton's pharmaceutics:

  • it refers to wide range of subject areas that are all associated with the steps to which a drug is subjected towards the end of its development
• according to university of mississippi

  • discipline of pharmacy that deals with the science of dosage form design and embraces all facets of the process of turning a new chemical entity into a medication that can be safely and effectively used by patients in the community
• according to the university of iowa:

  • multidisciplinary science that examine the development, production and characterization off dosage forms, as well as the disposition and action of drugs in the body
• areas of pharmaceutics

  • physical pharmacy
  • pharmaceutical manufacturing
  • pharmaceutical microbiology
  • product performance testing
  • compounding
  • biopharmaceutics
  • dosage form design
• physical pharmacy

  • area of pharmacy that deals with the quantitative and theoretical principles of physicochemical science as they are applied to the practice of pharmacy
• pharmaceutical manufacturing

  • production of medicine on a large scale
  • use of complex machines and equipment
• pharmaceutical microbiology

  • prevention and elimination of microorganisms in the medicines
• product performance testing

  • evaluation of medicine based on its design specification and intended use
• biopharmaceutics

  • examines the interrelationship of the physical/chemical properties of the drug, the dosage form, the route of administration on the rate and extent of systemic drug absorption
• dosage form design

  • design and formulation of medicines
• compounding

  • preparation of medicines on a small scale
  • can be done by hand / use of laboratory apparatus and glasswares
• in pharmaceutics I

  • physical pharmacy
  • dosage form design
  • compounding
• RA 10918 - Philippine pharmacy act

  • compounding - sum of processes performed by a pharmacist in drug preparation:

  1. calculations
  2. mixing
  3. assembling
  4. packaging
  5. labeling of a drug

  i. as the result of a prescription or drug order by a physician, dentist, or veterinarian

  ii. for the purpose of, in relation to, research, teaching or chemical analysis
• USP-NF

  • compounding- preparation of drug dosage forms for both human and animal patients
  • preparation, mixing, assembling, altering, packaging, and labeling of a drug-delivery device or device
  • in accordance with a licensed practitioner's prescription, medication order, or initiative
  • based on the practitioner, patient, pharmacist, compounder relationship
• patient-specific medications

  • used in compounding
  • unique per patient
  • label: write drug and adjusted dose legibly
  • factors to consider: age, gender, weight, special populations (pediatric, hepatically and renally-impaired, geriatic)
• manufacturing (versus patient specific medication)

  • batch master formula
  • simply follow instructions to have a tablet of desired batch of the particular operation
• coverage of compounding

  • preparation of drug dosage forms for both human and animal patients