1. As blood travels at high pressure in the arteries towards the capillaries, pressure filtration occurs which causes plasma to pass through capillary walls into the tissue fluid surrounding the cells
2. Tissue fluid and blood plasma are similar in composition, with the exception of plasma proteins, which are too large to be filtered through the capillary walls
3. Tissue fluid supplies cells with useful substances such as glucose, oxygen and other substances
4. Carbon dioxide and other metabolic wastes diffuse out of the cells and into the tissue fluid to be excreted
5. Oxygen diffuses through the capillary wall, into the tissue fluid, and the cells
6. Carbon dioxide diffuses from the cells into the tissue fluid, then across the capillary walls into the blood plasma
7. Glucose diffuses from the blood plasma, across the capillary walls to the tissue fluid, and then to the cells
8. The waste product, urea, diffuses from the cells of the liver to the tissue fluid, and then across the capillary walls into the blood plasma
9. Much of the tissue fluid returns to the blood. Lymphatic vessels absorb excess tissue fluid and return it as lymph to the circulatory system