Psych

• What is the interaction between SSRIs and NSAIDs?

  Increased risk of GI bleeding; give a PPI
• What is the SSRI of choice for children and adolescents?

  Fluoxetine
• How do you calculate alcohol units?

  Volume (ml) * ABV / 1,000
• What do benzodiazepines enhance in the brain?

  The effect of GABA, the inhibitory neurotransmitter
• What is a risk associated with antipsychotics in the elderly?

  Increased risk of stroke and VTE
• What are the features of anorexia nervosa regarding hormone and substance levels?

  Most things low, but G's and C's raised
• What is a common side effect of atypical antipsychotics?

  Weight gain
• What are the timelines for alcohol withdrawal symptoms?

  6-12 hours for symptoms, 36 hours for seizures
• What is the strongest risk factor for psychotic disorders?

  Family history
• Why should SSRIs and MAOIs never be combined?

  Risk of serotonin syndrome
• How long should antidepressants be continued after symptom remission?

  At least 6 months
• What are symptoms of SSRI discontinuation syndrome?

  Dizziness, electric shock sensations, anxiety
• What type of antidepressant is mirtazapine?

  Noradrenergic and specific serotonergic antidepressant
• What is a life-threatening side effect of clozapine?

  Agranulocytosis/neutropenia
• What syndrome is a complication of Wernicke's encephalopathy?

  Korsakoff's syndrome
• What is a risk factor for generalized anxiety disorder?

  Being divorced or separated
• What is the first-line treatment for children with anorexia nervosa?

  Anorexia focused family therapy
• What do personality disorders involve?

  Pervasive undesirable personality traits
• What characterizes mania?

  Persistently elevated mood state with psychotic symptoms
• Which atypical antipsychotic has the most tolerable side effect profile?

  Aripiprazole
• What should be done if clozapine doses are missed for more than 48 hours?

  Restart the dose slowly
• What is recommended for patients with poor oral compliance to antipsychotics?

  Consider once monthly IM antipsychotic depot injections
• What is 'word salad' associated with?

  Disorganized speech in psychosis and mania
• When should a CT head scan be considered in elderly patients?

  New sudden onset psychosis
• What is the SSRI of choice post-myocardial infarction?

  Sertraline
• What are SSRIs used for in generalized anxiety disorder?

  First-line pharmacological therapy
• What does thought withdrawal refer to?

  Belief of having a thought removed by an external force
• What is catatonia?

  Stopping of voluntary movement or staying still
• What is a risk associated with SSRI use during the third trimester?

  Persistent pulmonary hypertension of the newborn
• What is the mechanism of action of duloxetine?

  Serotonin-norepinephrine reuptake inhibitor (SNRI)
• What is the mechanism of action of venlafaxine?

  Serotonin-norepinephrine reuptake inhibitor (SNRI)
• What is a risk of paroxetine use in pregnancy?

  Increased risk of congenital malformations
• What is a risk associated with SSRI use in the first trimester?

  Small increased chance of congenital heart defects
• What is a common side effect of clozapine?

  Constipation/intestinal obstruction
• What syndrome is characterized by believing one is dead or non-existent?

  Cotard syndrome
• What should be ruled out in anxiety disorders?

  Thyroid disease
• What is a risk factor for Charles-Bonnet syndrome?

  Peripheral visual impairment
• What is Othello syndrome characterized by?

  Delusional jealousy about a partner's fidelity
• What is the difference between an obsession and a compulsion?

  An obsession is an intrusive thought; a compulsion is an action
• How can depression be differentiated from dementia?

  Depression has a short history and rapid onset