DNA Damage

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Created by
Sharifa Lomiyev

Cards (2)

  • dsDNA breaks are detected by p53 activation
    • dsDNA breaks trigger a complex signalling system that leads to the activation of ATM/ATR kinases which phosphorylate Chk1/2 kinases which phosphorylate p53 to be stable and active
    • no DNA damage -> p53 off -> Mdm2 binds to p53 to keep off and cause ubiquitination/degradation
    • DNA damage -> p53 on/phosphorylated -> dissociates from Mdm2 and transits to nucleus to bind to DNA as TF like gene p21 -> CDK inhibitor, cause cell cycle arrest by binding cyclin/CDK protein complexes (factors for cell growth)
  • p53 is a master regulator of stress/damage responses