+evidence other brain differences associated gender dysphoria. rametti 2011 studied another sexually dimorphic aspect of the brain white matter. there are regional differences in the proportion of white matter in male and female brains. rametti analysed the brains of both male and female transgender individuals, crucially before they began hormone treatment as part of gender reassignment. in most cases the amount and distribution of white matter corresponded more closely to the gender the individuals identified. suggests early differences in the brains of transgender individuals