Electrical impulses arrive at the end of the axon on the presynaptic neuron, neurotransmitters are released from the vesicles at the pre-synaptic membrane + they diffuse across the synaptic cleft + bind with receptors on the post synaptic membrane - this stimulates the postsynaptic neuron to generate an electrical impulse that travels down the axon, the neurotransmitters are then destroyed or recycled to prevent continued stimulation