Substance used in addition to or instead of conventional treatment
Alternative medicine
Substitute for more traditional or mainstream treatment
Examples of alternative medicine
Herbal remedies
Naturopathic treatments
Derived from 'nature' or 'natural source' does not mean it must be safe or that you can take as much as you want
FDA requirements for prescription products
Adhere to strict variability standards (maximum of 5% deviation between batches)
Supplements, herbals, and vitamins/minerals
Not FDA-regulated, variability could be + / - 100% (0% or 200% in the bottle)
Adverse effects of supplements
Difficult to predict, interactions are very common, variability in pharmacokinetics can affect incidence of side effects, prolonged use or excessive dosages can produce toxic effects
Bee Venom
Common uses: Multiple sclerosis, Rheumatoid arthritis, autoimmune disorders
Evidence: Some positive outcomes
Side effects: Painful, allergic reaction
Honey - MANUKA HONEY
Common uses: cough and colds,wounds,asthma,diabetes,cancer,infections,heart disease
Evidence: Strong for cough and cold, growing positive support for use in cancer,wounds, and diabetes
Side effects: Allergic reactions (ex. History of bee pollen allergy), not safe for children <12 months old (Clostridiumbotulism)
St. John's Wort
Common uses: Mild-moderate depression
Evidence: Decent for mild-mod depression, limited for others
Side effects: photosensitivity, insomnia, anxiety, dry mouth, dizziness, GI symptoms, fatigue, headache, sexual dysfunction
Dangerous, life-threatening interactions with many medications (ex. Antidepressants, birth control, some heart medications, warfarin)
Echinacea
Common uses: Stimulate or support immune function; colds and other mild respiratory tract infections; topical burns / wounds
Evidence: Support for reducing sx of common cold when taken quickly after symptoms appear; could help prevent colds if taken regularly
Side effects: GI upset, skin rash, allergic rxns
Garlic
Common uses: CVD risk reduction; antineoplastic, antimicrobial, anti-inflammatory, antihyperglycemic, antioxidant
Evidence: Support is mixed, May reduce total cholesterol and LDL (small effect, >8 weeks), may help high BP
Side effects: Generally mild (garlic odor, GI upset); with other antiplatelet drugs can cause serious bleeding
Ginkgo Biloba
Common uses: Allergies, anxiety, dementia, peripheral artery disease, vertigo
Evidence: No conclusive evidence to date FOR DEMENTIA
Common uses: Sleep, anxiety, digestive issues (C/D, gas), cold and flu, rapid heart rate, ASCVD
Evidence: Mild positive evidence, small studies to date
Side effects: heart damage with frequent use, allergic reactions, reduced lithium elimination, mouth and stomach sores
Melatonin
Common uses: Jet lag, falling asleep, sleep disorders in children, anxiety before and after surgery
Evidence: Better than placebo for sleep disorders and anxiety prior to surgery, but mixed for after surgery
Side effects (incl. kids): Drowsiness, increased urination in evening, headache, dizziness, agitation
Interacts with some anticoagulants and seizure medications
Glucosamine and Chondroitin
Common uses: Osteoarthritis
Evidence: Inconsistent results and conflicting conclusions, esp. for knee, hip hand, and temporomandibular joint
Side effects: Increased blood glucose, increased bleed risk (w /warfarin)
Caution with anticoagulants / antiplatelets as may increase bleeding risk!
Saw Palmetto
Common uses: Benign prostatic hyperplasia (BPH), chronic pelvic pain, migraine, hair loss
Evidence: Low quality for BPH
Side effects: mild GI upset, headache
Red Yeast (Red Rice)
Common uses: Cholesterol
Evidence: Monacolin K (large amounts) may reduce blood cholesterol, blood glucose, and blood pressure (considered unapproved drugs by FDA and are illegal in US!)
Side effects: Myopathy, kidney and liver damage, diarrhea, cramping
Wide variability in monacolin K content in red yeast (red rice) supplements
Refers to all products derived from plant Cannabis sativa, containing 540 chemical substances, some with very little THC and called "industrial hemp" under US law
Marijuana
Refers to parts of or products from Cannabis sativa that contain substantial amounts of tetrahydrocannabinol (THC), the substance primarily responsible for mental effects
Only 3 drugs are FDA-approved cannabinoids: Epidiolex, Marinol, Syndros, and Cesamet
THC or CBD-containing products cannot be legally sold as dietary supplements or in interstate commerce
Evidence for use of cannabis and cannabinoids
May be helpful for rare epileptic disorders, nausea and vomiting from chemotherapy, loss of appetite and weight loss caused by HIV
Modest benefits possible for chronic pain and multiple sclerosis
Unhelpful for glaucoma, little evidence for reduced anxiety
Passing medical marijuana laws has NOT been associated with less nonmedical prescription opioid use
Higher death rates in states with medical marijuana laws from opioid overdoses
Risks of cannabis and cannabinoids
Increased risk of psychosis or schizophrenia, motor vehicle crashes, orthostatic hypotension, recurrent severe vomiting (long-term high dose), contaminated/laced product
Cannabis use disorder: withdrawal/cravings, lack of control, negative effects on personal and professional responsibilities
Adolescent use -> 4-7x more likely to develop cannabis use disorder
Adverse reactions to CBD
Decreased alertness, mood changes, decreased appetite, GI (ex. Diarrhea), liver injury, male reproductive harm, sleepiness, frequent drug interactions
Look for third-party random testing, good manufacturing practices, and less ingredients on supplement packages
Brands commonly recommended by pharmacists
Centrum
Nature Made
Nature's Bounty
Vitafusion
Energy drinks
Contain 70 to 240 mg of caffeine per 16 oz bottle or 113 to 200 mg per "energy shot" of concentrated liquid, used to increase energy and enhance mental alertness and physical performance
Evidence and side effects of energy drinks
Works as caffeine is known to work, ER visits common with 1 in 10 leading to hospitalization
Serious heart arrhythmias, inc heart rate and BP, anxiety, sleep disturbances, digestive issues, and dehydration
Protein powder
Used for muscle building, wound healing, weight gain, nutritional boost
Evidence and side effects of protein powder
Some support
High calorie content (weight gain), extra sugar/processed ingredients, contamination is common, constipation
Creatine
May somewhat enhance effects of exercise on strength, muscle mass, and endurance, but long-term effects not well studied
Essential oils
Used for mood, sleep, anxiety, pain, inflammation, nausea, most common types include lavender, tea tree, peppermint, eucalyptus, lemon, lemongrass, orange, rosemary, bergamot, cedarwood
Evidence and side effects of essential oils
Some mixed results, only small amounts for short durations
Relatively safe when inhaled, diffused, or applied in small amounts topically
Vitamins
Organic chemicals needed by the body to facilitate metabolic and biosynthetic processes, relatively balanced diet provides adequate vitamins needed
Fat soluble vitamins
A, D, E, and K
Excessive dosages of fat soluble vitamins can accumulate and cause harm in tissues and organs
Minerals
Chemical substances involved in physiological processes, often essential for life, trace minerals are not abundant in the body but needed to promote functions of specific cells and tissues