The Macbeths pursue a facade of innocence while plotting their murders, and as they descend further into their web of violence, they long to regain their lost innocence
Focused on the murder, as he expresses his greatest remorse directly before and after he kills Duncan. After that, his guilt comes in the form of paranoia, and this sends him on a frenzied murder spree
Macbeth: '"For Banquo's issue have I filed my mind; / For them, the gracious Duncan have I murdered, / Put rancours in the vessel of my peace / Only for them,"'
Lady Macbeth's guilt makes her go into herself, closing herself off to everyone else, cannot be in darkness, and sleep walks as she is trapped in her own guilty thoughts
The way her guilt takes over is gradual but destructive, showing how even the most callous and cold people aren't immune to God's judgement and their own human conscience
Lady Macbeth: '"Stop up th'access and passage to remorse / That no compunctious visitings of nature / Shake my fell purpose nor keep peace between / Th'effect and it,"'
Lady Macbeth: '"Nought's had, all's spent / Where our desire is got without content. / 'Tis safer to be that which we destroy / Than by destruction dwell in doubtful joy,"'