AUTOLOGOUS DONATION | XM

Cards (37)

  • Refers to removal and storage of blood or blood components from a donor-patient before an elective procedure, for reinfusion during or after the procedure
    Preoperative Collection (Predeposit)
  • Blood is collected before a surgical procedure and simultaneously replaced a comparable volume of crystalloid or colloid solution. Blood collected can be saved and retransfused as fresh whole blood
    Acute Normovolemic Hemodilution
  • Involves collection and reinfusion of blood lost by a patient during the surgery a device that utilizes vacuum is used to collect shed blood; blood is then washed with saline and then concentrated to reach a hematocrit of 50 to 60%
    intraoperative Collection
  • Blood is collected from a drainage tube placed at the surgical site. It is reinfused with or without processing via a microaggregate filter to screen out any debris
    Postoperative Collection
  • is a unit collected under the same requirements as those for allogeneic donor, except that the unit collected is directed toward a specific patient.
    Directed Donation
  • Derived from a greekword “aphairos” which means “to separate or remove or take from”
    APHERESIS
  • Use anticoagulants tp prevent blood from clotting as it enters the separation machine-the most common anticoagulant is _____
    acid citrate dextrose
  • Performed in cycles or passes
    Intermittent flow centrifugation
  • blood is drawn and reinfused through the same needle
    one-arm procedure
  • blood is drawn on one arm and reinfused on the other arm.
    two-arm procedure
  • Involves withdrawal, processing and reinfusing of blood to the individual simultaneously. Does not involve cycles or passes.
    CONTINOUS FLOW CENTRIFUGATION
  • uses filters to separate continuously and would require two arms for the procedure.
    BY FILTRATION
  • PLATELETPHERESIS donor should have at platelet count of at least _____
    150 x10/uL
  • Platelet unit taken from apheresis is known as the single donor platelet. It is equivalent to __-__ random platelet concentrate
    6-10
  • 75% of plateletpheresis products tested should contain a minimum of _____ platelets and the pH at the end of the storage period must be ____ or greater
    3.0x 10 ; 6.2
  • Serum/plasma should be tested for total protein and serum electrophoresis or quantitative Ig
    PLASMAPHERESIS
  • Granulocyte concentrate from leukapheresis are needed for patients who are severely neutropenic and have infections that are not responsive to antibiotics.
    leukapheresis
  • is administered to acts as an RBC sedimenting agent to allow better separation and improved yield while minimizing RBC contamination.
    Hydroxyethyl starch (HES)
  • increase the number of circulating granulocytes by release of the marginal pool and slow their departure from the intravascular space.
    Corticosteroids (prednisone/ dexamethasone)
  • are growth factors that increases the number of granulocytes harvested
    Granulocyte-colony stimulating factor(G-CSF)
  • Standardized RBC mass collection (180 to 200 ml)
    ERYTHROCYTAPHERESIS
  • May be used to increase the inventory of fresh frozen plasma of particular ABO groups such as type AB. Can be used to collect immune plasma from donors with increased concentrations of certain plasma immunoglobulins for patients who are immunosuppressed
    PLASMAPHERESIS
  • Can be used to remove substance that exists in the blood that contributes to a disease process or its symptoms.
    THERAPEUTIC CYTAPHERESIS AND THERAPEUTIC PLASMAPHERESIS
  • refers to removal of cellular components as a form of treatment or to alleviate the symptoms in the patient.
    Therapeutic cytapheresis
  • refers to removal of plasma components
    Therapeutic plasmapheresis
  • can be used to treat patients with abnormally elevated platelet counts such as in myeoloproliferative disorders.
    Therapeutic thrombocytopheresis
  • can be a treatment to a patient with leukemia.
    Leukopheresis
  • can be used to remove plasma factors such as immune complexes, autoantibodies,alloantibodies, antibodies causing hyperviscosity, inflammatory mediators, protein-bound toxins, excessive lipoproteins and platelet aggregating factors
    Plasma exchange or plasmapheresis
  • In vitro crossmatch is most often performed; however, an _______ crossmatch can also be used especially if the patient is serologically incompatible with all or most of donor units.
    in vivo
  • has emerged as an acceptable alternative to crossmatching blood.
    TYPE AND SCREEN PROCEDURE
  • Minor crossmatch has now been widely replaced by
    antibody screening
  • DONOR RBCs+ PATIENT SERUM
    Major Crossmatch
  • DONOR SERUM+ PATIENT RBCs
    Minor Crossmatch
  • PATIENT RBCs+ PATIENT SERUM
    Autocontrol
  • first phase of XM
    Immediate Spin/ Room temperature phase
  • second phase of xm
    37 deg Celcius WITH ENHANCEMENT MEDIA
  • third phase of xm
    ANTI-HUMANGLOBULIN (AHG) PHASE