Antiplatelets

Cards (7)

  • Antiplatelets
    Used to prevent thrombosis in the arteries by suppressing platelet aggregation
  • Anticoagulants
    Heparin & warfarin, prevent thrombosis in the veins
  • Antiplatelets
    • Decrease the formation of the platelet plug by decreasing the responsiveness of the platelets to various stimuli that would cause them to stick and combine together on a vessel wall
  • Antiplatelets - Mechanism of Action
    Inhibits the aggregation of platelets in the clotting process by blocking receptor sites on the platelet membrane, preventing platelet-to-platelet interaction, thereby prolonging the bleeding time
  • Antiplatelets - Prototypes
    • COX Inhibitors: Aspirin
    • Adenosine Diphosphate (ADP) antagonists: clopidogrel, dipyridamole
  • COX Inhibitors: Aspirin
    Inhibits cyclooxygenase (COX), the enzyme needed by platelets to synthesize thromboxane A2 (TxA2)
  • Adenosine Diphosphate (ADP) antagonists: clopidogrel, dipyridamole
    Affect platelet aggregation