Over 100,000 people would be killed instantly due to the blast and pyroclastic flow - within 1000km 90% of the population could be killed
Most of North America would be completely uninhabitable
Crops and food supplies would suffer greatly, and prices would increase dramatically. Global famine and mass starvation would be inevitable
Water supplies would be contaminated
Respiratory and general health problems would increase
Ash thrown into the upper atmosphere will circulate around the globe and cause a 'dark summer` where no sunlight would get through for at least a year
Global temperatures would drop by at least 3-5oC and remain low for many years. Depending on the drop it could trigger and ice age
Buildings would be crushed by the ash fall
The Global economy would collapse