ancient form of disease found in all multicellular plants and animals
Adaptive Immunity is found only in vertebrates
Cellular barriers to infection;
can react within minutes of microbial invasion
some activated cells directly kill microbes while others recruit other cells
Chemical Barriers
molecular factors that provide innate immune protection against infection
Antimicrobial peptides and proteins
molecules released by several cell types, some are consitiuitvly secreted while others can be induced
Epithelial
a specialized cell type that protects the body from external stimuli, line all body cavites
endothelial
specialized cells that line organs that are not continuous with the external surface
mucus in the respirtory tract helps trap bacteria and pathogens
Properties of AMP;
10-50 aa
cysteine rich
cationic
amphipathic
commensal microorganism
rhe diverse community of microebs that coexist with our barriertissues without casuinf damage
inflammation
tissue response to infection or damage that eliminates or contains the insult
Phagocytosis
the cellualr uptake of particular materials by engulfment
innate immune cells mount the first line of defense agaisnt pathogens
antigen presenting cells communicate the infection to lymphoid cells
Primary lymphiod organs are the spleen, lymph nodes, and tonsils— mature immunocompetent cells encounter trapped antigens and are activated into effector cells
