Absorbed almost entirely by the liver as most cells lack its transporter glut-5, does not stimulate insulin release, poorly absorbed from gastrointestinal tract, does not suppress grehlin, predominantly absorbed passively from the intestinal lumen via the hexose transporter SLC2A5, also known as GLUT5, which has high affinity for fructose (Km = 6 mM), rapidly phosphorylated by ketohexokinase (KHK, also known as fructokinase) to generate fructose-1-phosphate (F1P), F1P is metabolized to dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P), which enter the glycolytic/gluconeogenic metabolite pools