Some neurotransmitters are excitatory and some are inhibitory. Excitatory neurotransmitters makes the post synaptic cell more likely to fire, inhibitory neurotransmitters makes them less likely to fire. excitatory neurotransmitter binds to the post-synaptic receptors, cause an electrical charge in the cell membrane which results in excitatory postsynaptic potential and makes the post-synaptic cell more likely to fire. If an inhibitory neurotransmitter binds to the post-synaptic receptors, it will result in an inhibitory post-synaptic potential makes the post-synaptic cell less likely to fire.