“SorrowisKnowledge, they who know the most must mourn the deepest o’er the fatal truth, theTree of Knowledge is not that of Life.” (knowledge comes with the awareness of mortality - build on this)
“grief, the instructor of the wise.”
“I dwell inmydespair— And live—and live for ever,” → melancholy becomes a tangible location
"We are all the fools of time and terror: Days Steal on us and steal from us; yet we live, Loathing our life, and dreading still to die."
Manfred is set in the Alps (Wordsworth and Shelley both also went here - a key melancholic site); contributes to the solitude of Manfred.