The study of heredity and the variation of inherited characteristics
Cell cycle
The series of events that a cell goes through from the time it is first formed until it divides into two new cells
Why does a cell divide
Growth
Repair of damaged tissues and organs
Replace dying or dead cells
Cell division time
Can range from 8 minutes to over a year (e.g. liver cells), average is 12-24 hours
Stages of the cell cycle
Interphase
Mitosis
Cytokinesis
Interphase
Period between cell division
Cell functions normally during this period
Phases of Interphase
G1 phase (growth)
S phase (Synthesis - DNA synthesis and replication)
G2 phase (growth 2 - cell prepares for division)
Cell cycle movement through stages is a continuous process
Cell division occurs in somatic cells (body cells)
Cell division occurs in healthy animal cells
Interphase
DNA is in the form of uncondensed strands called chromatin
Chromatin
Thin
Long
Once mitosis begins, chromatin will condense to form chromosomes
Replicated chromosomes are attached to each other at the centromere
Mitosis
Ensures that the two daughter cells created are identical to each other and to the original
Genetic continuity
The transmission of hereditary material through cell division
Mitosis requires both the division of genetic material and the division of the cytoplasm
Mitosis Stages
1. Prophase
2. Metaphase
3. Anaphase
4. Telophase
In prophase, chromatin condenses into visible chromosomes, the nuclear membrane breaks down, and the nucleolus disappears
In metaphase, chromosomes move and line up in the middle of the cell, and spindle fibers attach to the centromere of each pair of chromatids
In anaphase, centromeres divide and chromatids move to opposite poles as spindle fibers shorten
In telophase, chromosomes lengthen and intertwine, losing their distinct shape, the spindle fibers dissolve, and the nuclear membrane begins to form around each mass of chromosomes
Cytokinesis
Marks the end of telophase, the division of cytoplasm and cell contents into roughly equal portions, creating two genetically identical daughter cells
Animal cell cytokinesis
Cytoplasm pinches in at the equator producing a cleavage furrow
Plant cell cytokinesis
A cell plate forms at the equator which will develop into a new cell wall, no centrioles, astral rays or astral fibers
Cell division in prokaryotic cells
Occurs through binary fission, no true nucleus
DNA
Deoxyribonucleic acid, double helix structure with deoxyribose (sugar) and phosphate backbone, four nitrogen bases
Complementary base pairing
Adenine always bonds to thymine, guanine always bonds to cytosine
DNA replication
Occurs in interphase, each strand serves as a template for a new strand, new strands created according to complementary base pairing
Chromatin
DNA coils around proteins to form chromatin, chromatin folds up to make chromosomes
The number of chromosomes in a cell varies between species, but the number of chromosomes does not reflect the complexity of the organism
Homologous chromosomes
Each chromosome is part of a homologous pair, one from each parent
Sex chromosomes
X and Y chromosomes determine the gender of the individual
Autosomes
All chromosomes other than the sex chromosomes
In karyotyping, autosomes are arranged from largest to smallest and labelled 1 through 22, sex chromosomes are placed at the end and identified as X or Y
Somatic cells
Non-reproductive cells that form the body of the organism, created by mitosis
Asexual reproduction
Requires only one parent and produces genetically identical offspring
Sexual reproduction
Requires reproductive cells to combine during fertilization to form a zygote, produces offspring genetically different from either parent
The zygote has the same number of chromosomes as the somatic cells of that organism
Gametes
Reproductive cells that contain half the number of chromosomes (haploid) compared to somatic cells (diploid)