Cards (7)

    • Histamine 2 receptor antagonists
      inhibit acid secretion to treat GERD, ulcers, heartburn, and indigestion
    • H2RA pharmacodynamics
      Reversible competitive blockers of histamine at histamine 2 receptors
      highly selective
      inhibits all phases of gastric acid secretion
      They do not inhibit acetylcholine unlike antihistamines
    • H2RA examples
      Cimetidine, Famotidine, Nizatidine, Ranitidine
    • H2RA precautions and contraindications
      Caution in renal impairment
      Ranitidine has least renal toxic effects, Cimetidine the most
      contraindicated in liver disease
      caution in liver impairment
    • Adverse reactions H2RAs
      Cimetidine has greatest risk of adverse reaction
      CNS effects, mental confusion, agitation, depression
      agranulocytosis, thrombocytopenia
      drowsiness, dizziness, constipation
    • H2RA monitoring
      monitoring should occur in those with liver or renal impairment
    • H2RA education
      take dose if missed but do not double the dose
      taken with meals or immediately after and at bedtime
      once daily are best taken at bedtime
      avoid taking with antacids or cytoprotective agents, wait at least 2 hours
      may cause drowsiness or dizziness
      cimetidine has the potential for gynecomastia and impotence
      don't smoke and eat right