•This approach to schizophrenia acknowledges the that a range of biological, psychological and societal factors are involved in the development of schizophrenia.•A diathesis-stress model is an interactionist approach to schizophrenia. Schizophrenia is argued to be the result of both an underlying (genetic) vulnerability (diathesis) and an environmental trigger (stress). Both are necessary for the onset of schizophrenia.