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cam 101
immunology
innate imunity
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dendritic cell
antigen presenting
to
T cells
natural killer cell
controls
viral infection
by
killing tumour
and
virus infected cells
neutrophil
mediate
early
inflammation
eosinophils
parasite
killing
and
contribute
to
asthma
mast cells
release
histamines
that activates
endothelium
and
increases blood vessel permeability
monocytes
short lived source of resident
macrophages
and
dendritic cells
macrophage
phagocytosis
,
angiogenesis
,
synthesis
of
collagen rich ECM,
and
wound healing
angiogenesis
new blood vessel growth
NK cells give
immunity
to
viruses
and
cancer
, and cause
chronic inflammation
ILC1 offers immunity to
intracellular bacteria
and
protazoa
, and cause
chronic inflammation
ILC2 offer immunity to
helminths
ILC give immunity to
extracellular bacteria
and cause
chronic inflammation
defensins
form
pores
lactoferrin
binds and transports
iron
, which is
anti bacterial
and
anti fungal
complement system is activated by recognition of
pathogens
complement system results in enhancement of phagocytosis via
opsonisation, inflammation,
and
lysis
of
microbes
C3b
binds to
microbe
for
phagocytosis
c3a
binds to
mast cells
to release
histamines
alternative pathway
c3b
binds to
activating
surfaces such as
cell walls
classical pathway
c1
binding to
antigen-antibody
complexes
lectin pathway
binding of
lectins
in
plasma
to
carbohydrates
on
microbes
c3a
inflammation
c3b
opsonisation
and
phagocytosis
c5a
inflammation
c6-9
lysis of microbe
c3b binds to
antibody
and becomes component of the enzyme that cleaves
c5
and initiates the
late
steps of
complement activation
c5b initiates late steps of
complement activation
, producing
c5a
c5b forms a complex with
c6-9
to form
MAC
MAC
makes
pores
in
membrane
to allow
water
and
ion movement
, resulting in
lysis
of
microbe
macrophages dont
circulate
,
trap
antigen
at site of
infection,
are derived from
monocytes
, and can produce
cytokines
inflammatory macrophages live for
days
to
weeks
tissue resident macrophages live for
years
neutrophils increase during
acute
inflammation
, and secrete
lysosomal enzymes
, first
cells
to migrate during
inflammation
pus is mostly
dead neutrophils
neutrophils are
short lived, 1-2 days
phagocytosis steps
chemotaxis, adherence, ingestion, digestion, killing
chemotaxis
movement of
phagocytes
to site of
damage
due to
chemical stimulus
adherence
attachment
of
phagocyte
to
microbe
oxidative bursts generate
oxygen radicals,
and
nitric oxide
opsonisation
microbes targeted for
destruction
for
phagocytes
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