Health

• Transforming Healthcare using:

  • Data
  • Technology
  • Analytics
• Data - provides a deeper understanding of each patient.
• Technology - offers new ways of collecting data and enhancing care.
• analytics - provide insights from data and technology
• Data driven health - confluence of science and technology with patient at the center.
• 137 terabytes of data everyday - amount of data that is being generated per hospitals.
• Medical Access Endpoints:

  • Economic Outcomes
  • Societal Outcomes
  • Organizational Outcomes
  • Clinical Genomic & HUmanistic Outcomes
• economic outcomes - impact of new intervention on patients and organizations, include direct and indirect costs, medical and non-medical cost of waiting times, healtcare resources utilization, cost drivers, financial incentives and reimbursement, cost effectiveness, waste.
• Healthcare Data Life Cycle :

  • Data Collection
  • Disclosure + Data Sharing
  • Storage
• Observational Medical Outcomes Partnership (OMOP)
• Observational Health Data Science and Informatics (OHDSI
• Real-world data (RWD) - Data relating to patient health routinely collected from a variety of sources outside of traditional controlled clinical interventional trials, under real-life clinical practice.
• Real-world Evidence (RWE) - the evidence derived from the analysis and/ or synthesis of RWD.
• primary use of health data - when health data is used to deliver healthcare and to make decisions about the care of the individual from who it was collected.
• secondary use of health data - use of aggregated health data from population-level sources to improve personal care planning, medicines development, safety monitoring, reasearch and policymaking.
• Gene Alteration Types:

  • Copy Number Alterations
  • Substitution
  • Insertion and Deletion
  • Rearrangements
• substitution - change of one base in DNA.
• insertion and deletion - addition or removal of bases in DNA.
• copy number alterations - duplication or loss of whole genes or segments of DNA.
• guardian genes - responsible for protecting cancer.
• oncogenes - causes cancer