▪Stone Age - used crude tools to cut vessels and drain blood from the body. ▪Ancient Egyptians - a form of "Bloodletting" (1400 B.C.) ▪Hippocrates (460 - 377 BC) - balance of the four humors, removing the excess by bloodletting. ▪Middle Ages – used to treat illness and performed by barbersurgeons ▪17th and 18th century – treated as major therapy