Weakness - Drug therapy isnt applicable to all patients due to their side effects. Common side effects include nausea, headaches, insomnia, loss of sex drive (Soomro et al). Tricyclic drugs have more serious side effects: hallucinations, weight gain, irregular heartbeat. Weakness because it reduces the effectiveness of SSRIs as people may stop taking them to avoid side effects. This decreases the appropriateness of SSRIs over psychological treatments like CBT which have no side effects. People with cardiovascular or sleep conditions can't take drug therapy.