one weakness of the cognitive approach is that it does not explain the origin of irrational thoughts. Since most of the research in this area is correlational, psychologists are unable to determine if negative, irrational thoughts cause depression, or whether a person’s depression leads to a negative mindset. Consequently, it is possible that other factors, for example genes and neurotransmitters, are the cause of depression and the negative, irrational thoughts are the symptom of depression.