Enlargement of extremities (spade- like hands)
Increase in ring, hat and/or shoe size
Carpal tunnel syndrome
Hyperhidrosis (increased sweating from sweat gland hypertrophy) & body odor
Coarsening of facial features
Prominent supra-orbital ridges
Prognathism (protrusion of the jaw)
Macroglossia (enlargement of the tongue) & deep voice
Dental indentation (from jaw growth)
Arthralgias from joints growing out of alignment
Increased incidence of obstructive sleep apnea
Hyperglycemia & increased incidence of glucose intolerance or frank diabetes mellitus
Acanthosis nigricans & skin tags
Hypertension resistant to Tx for unclear reasons in 50%
Increased incidence of congestive heart failure
Hyperphosphatemia, hypercalciuria, and hypertriglyceridemia
Colonic polyps and increased risk of colon cancer
Erectile dysfunction (prolactin co-secreted w/ pituitary adenoma)