There are several challenges to trying to figure out how, and to what extent, toxicants in air, water, and soil affect human health, what are they?
They are: 1. no unexposed control groups
2. animal models often underestimate human impact
3. humans are exposed to a toxic soup
4. developing brain is particularly sensitive during critical periods
5. long latency between exposure and effects
6. Impact can be magnified by other factors like malnutrition, genetics