No monotherapy approved, combination therapy required
Interferonalpha can also be used
Viral hepatitis is inflammation of the liver parenchyma, most commonly caused by hepatitis viruses A, B, C, D, and E
Routes of transmission for hepatitis viruses
Fecal-oral: HAV, HEV
Parenteral, sexual, perinatal: HBV, HCV, HDV
Hepatitis A virus (HAV)
RNA picornavirus with short incubation period, causes acute hepatitis with good prognosis
Hepatitis B virus (incubation T + common presentations)
DNA hepadnavirus with long incubation period (1-6 months), can cause acute hepatitis, chronic hepatitis, cirrhosis, or fulminant hepatitis
Hepatitis C virus (HCV) {Taxonomy + Incubation}
RNA flavivirus with long incubation period, commonly causes chronic hepatitis that can progress to cirrhosis or HCC
Hepatitis D virus
RNA delta virus that requires HBsAg to infect, can cause co-infection or super-infection in chronic HBV, associated with worse prognosis
Hepatitis E virus {Class + Incubation T + complications (2)}
RNA hepeviridae with short incubation period, causes self-limiting acute hepatitis, but can cause fulminant hepatitis in pregnant women
Measles (Who is affected?)
One of the most contagious infectious diseases and remains a leading cause of death particularly among young children especially in areas with low rates of vaccination