BB M8 & BLOOD COMPONENTS

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Created by
Anna Carmela

Cards (19)

  • 12 Blood Component
    • Whole Blood
    • Packed Red Blood Cells (pRBC)
    • Irradiated PRBC unit
    • Leukoreduced/Leukocyte-poor RBC
    • Washed RBC/Washed Platelets
    • Frozen/Deglycerolized/Washed Red Blood Cells
    • Random Donor Platelets
    • Single Donor Platelets
    • Fresh Frozen Plasma
    • Cryoprecipitated Antihemophilic Factor
    • Granulocyte Concentrate
    • Rho (D) Immune Globulin
  • Whole Blood
    • Storage: 1-6ºC
    • Expiration: ACD/CPD/CP2D: 21 days, CPDA-1: 35 days, CPDA-2: 42 days
    • Indication: Restore oxygen carrying capacity, Source material for blood component preparation to replace the loss of both RBC and plasma volume
  • Packed Red Blood Cells (pRBC)

    • Storage: 1-6ºC
    • Expiration: ACD/CPD/CP2D: 21 days, CPDA-1: 35 days, CPDA-2: 42 days
    • Indication: Restore oxygen carrying capacity
  • Irradiated PRBC unit

    • Storage: 1-6ºC
    • Expiration: Minimum of 28 days from the time of irradiation or the original outdate, whichever is sooner
    • Indication: Prevent the development of transfusion-associated graft-versus-host disease (TA-GVHD), Indicated for recipients of components collected from a blood relative or HLA-matched donor
  • For Irradiated PRBC unit, The FDA and AABB recommend a minimum dose of gamma irradiation of 25 Gy to the central portion of the blood unit, with no less than 15 Gy delivered to any part of the blood unit
  • Irradiation may be achieved by using either a radioactive source (Cesium-137 or Cobalt-60) or x-ray
  • To confirm a product was irradiated, a radiochromic film label is affixed to the component before it is placed into the metal canister of the irradiator. Darkening of the film confirms irradiation requirements
  • Leukoreduced/Leukocyte-poor RBC
    • Storage: 1-6ºC, Closed system: Same as for RBC, Open system: 24 hours
    • Indication: Reduce recurrent febrile non-hemolytic transfusion reactions, Reduce alloimmunization to leukocyte antigens that may complicate care of patients who undergo transplantation or chronic transfusion therapy, Protect against transmission of cytomegalovirus (CMV) to patients at increased risk of CMV disease
  • Leukoreduced components must have ≤5.0 X 10^6 residual white blood cells per each whole blood, red blood cells, or apheresis platelet, and ≤8.3 X 10^5 residual WBCs per each platelets derived from whole blood
  • ≥85% of the original component must be recovered after leukoreduction
  • Washed RBC/Washed Platelets

    Washed RBCs: Storage: 1-6ºC, Expiration: 24 hours
    Washed platelets: Storage: 20-24ºC, Expiration: 4 hours
    Indication: For patients who have severe allergic reactions to proteins found in the residual plasma; for patients whose allergic reactions are anaphylactic or anaphylactoid in nature and cannot be effectively mitigated with medication prior to transfusion, For removal of antibody, Removal of other substances of clinical concern. One example is to remove potassium and avoid hyperkalemic cardiac arrhythmias or arrest due to potassium leakage in RBC components
  • Frozen/Deglycerolized/Washed Red Blood Cells
    Frozen: Storage: -65ºC or -120ºC, Expiration: 10 years
    Deglycerolized: Storage: 1-6ºC, Expiration: 24 hours
    Indication: For those patients with rare phenotypes, for autologous use, and for the military to maintain blood inventories around the world for U.S. military use, Since all donor plasma is removed, deglycerolized, and washed, red blood cells can be used for patients with paroxysmal nocturnal hemoglobinuria and IgA deficiency with circulating anti-IgA
  • Random Donor Platelets

    "Whole Blood" ; Require 4-6 unit
    Increase Patient Platelet Count by 5000-10000/uL
    Storage: 20-24ºC with continuous gentle agitation,
    Expiration: 3-5 days (>7 days- bacterial growth)
    Indication: To correct thrombocytopenia due to decreased platelet function, decreased platelet production, or increased platelet consumption (bleeding, platelet disorders, DIC, massive transfusion)
    First Line of defense against thrombocytopenia
  • Single Donor Platelets

    "Apheresis" only 1 unit
    Increase Platelet count by 20000-60000/uL
    Storage: 20-24ºC with continuous gentle agitation,
    Expiration: 3-5 days
    Indication: To correct thrombocytopenia in patients who demonstrates refractoriness to random donor platelets (platelet alloantibodies)
    Last Line of defense against thrombocytopenia
  • Fresh Frozen Plasma

    Storage: -18ºC or -65ºC, Expiration: -18ºC = 1 year, -65ºC = 7 years
    Indication: Treatment of multiple coagulation factor deficiencies, Contain the maximum levels of both stable and labile clotting factors
    It can be transfused regadless of Rh type
  • Cryoprecipitated Antihemophilic Factor

    Storage: -18ºC, Thawed at 30-37ºC and stored at RT (22-24ºC), Expiration: Frozen = 1 year, Thawed= 6 hours, Pooled= 4 hours
    Indication: Correction of Factor VIII deficiency (Hemophilia A, von Willebrand factor), The process for isolating factor VIII also harvests fibrinogen, factor XIII, von Willebrand factor (vWF), cryoglobulin, and fibronectin, In recent years, cryoprecipitate has also been used to make fibrin glue, a substance composed of cryoprecipitate (fibrinogen) and topical thrombin
  • Cryoprecipitate contains at least 80 units of AHF activity and at least 150 mg of fibrinogen
  • Granulocyte Concentrate
    Storage: 20-14ºC without agitation, Expiration: 24 hours
    Indication: Correct severe neutropenia (< 500 PMN/mL), Fever unresponsive to antibiotic therapy, Myeloid hypoplasia of bone marrow
  • Rho (D) Immune Globulin
    Storage: 1-6ºC, Expiration: 3 years
    Indication: Prevention of Rho (D) immunization, Prevention of Rh HDFN