1. AP endonuclease makes a nick for DNA polymerase to bind
2. The Mut system is critical in this process
3. MutS recognizes mismatches/damage and binds to them
4. MutL binds and stabilizes the complex
5. MutS-MutL activates MutH, which nicks the newly synthesized strand opposite the nearest methyl group (after replication therefore damage likely on newly synthesized strand)
6. MutU (Helicase II) unwinds the DNA from the nick towards the mismatch
7. DNA PolI then degrades and replaces the unwound DNA, and DNA ligase seals the break