Filipinos from the Butuan were trading with Champa (Vietnam)
Filipinos from Ma-I (Mindoro) with China (bee wax, cotton, pearls, coconut heart mats, tortoise shell and medicinal betel nuts, panie cloth for porcelain, leads fishnets sinker, colored glass beads, iron pots, iron needles and tin)
Successive shipwrecks of and attacks of pirates on the galleons led to declining profits from the trade that led to economic depression in Manila during the later part of the 17th century
The Real Sociedad Economica de los Amigos Del Pais de Filipinas founded by Governador Jose Basco y Vargas in 1780 encouraged research in agriculture and industry
Manila was opened to Asian shipping, inaugurating an era of increase in export of rice, hemp, tobacco, sugar, and indigo, and imports of manufacturing goods
Creation of Department of Public Instruction which offers free and compulsory elementary (600 teachers from USA taught in Philippines, Philippine Normal School, Philippine Medical School)
Promotion of higher education in sciences and government research institution and agencies performing technical function (Liberal Arts, Veterinary medicine, law)
Creation of Bureau of Science as government research establishment and training ground of Filipino Scientist (Vaccines, dse like leprosy, tuberculosis, cholera, dengue fever, malaria and beri-beri and scientific developments)
Proliferation of schools and many of them were ill-equipped and ill-prepared to provide quality education particularly in sciences and engineering (Standards)
UP system remains the most developed with extensive graduate and undergraduate degree programs in the sciences and engineering (half of the national budget for SUC's)