Prefinal Clinpar 1

• Toxoplasma gondii a protozoan parasite that infects most species of warm- blooded animals, including humans.

  Causes the disease toxoplasmosis.

  Definitive host is family Felidae.
• The life cycle of Toxoplasma involves sexual reproduction within cats (definitive hosts) and asexual reproduction within intermediate hosts such as rodents, birds, and humans.
• Cyst  Of T. gondii

  •5-50 um in diameter

  • spherical in brain but elongated in cardiac and skeletal muscles.
• Cysts of T. gondii most common in brain and skeletal and cardiac muscles.
• T. gondii trophozoite

  Size: 4-8 um long × 2-3 um wide

  • tapered anterior end
  • blunt posterior end
  • Large nucleus
• Infective stage of T. gondii

  • tachyzoite
  • Bradyzoite
  • Oocyst
• Asexuals stages of T. Gondii

  • Tachyzoites
  • Bradyzoites
• T. Gondii can be seen in the CNS.
• Similar to Plasmodium falciparum. T. Gondii
• Common manifestation of T. Gondii in humans. Lymphadenitis
• Severe manifestation of Toxoplasmosis in immunosuppressed patient with AIDS . Encephalitis
• Diagnosis for T. gondii.

  • Tested for IgG antibody to detect latent infection.
  • PCR specimen taken e.g serum, amniotic fluid ,cerebrospinal fluid
• Treatment for T gondii.

  • Pyrimethamine (25 mg daily) and sulfadiazine (1-1.5 g four times daily)combination for one month.
• T. gondii for immunocompromised patients -trimethoprim-sulfamethoxazole