John Snow's investigation of the cholera outbreak in Soho, London in 1854
1. Observation: Cholera outbreaks near a water pump in Broadwick Street, cholera affected the digestive tract
2. Observation: Victims had drunk from the pump, people nearby who drank beer did not get cholera
3. Hypothesis: Cholera was picked up from the water in the pump
4. Experiment: Blocked off the pump by removing its handle
5. Result: The cholera epidemic died out