How changes in membrane permeability lead to depolarisation and the generation of an action potential
1. Stimulus: Na+ channels open; membrane permeability to Na+ increases, Na+ diffuse into axon down electrochemical gradient (causing depolarisation)
2. Depolarisation: If threshold potential reached, an action potential is generated, as more voltage-gated Na+ channels open (positive feedback effect), so more Na+ diffuse in rapidly
3. Repolarisation: Voltage-gated Na+ channels close, Voltage-gated K+ channels open; K+ diffuse out of axon
4. Hyperpolarisation: K+ channels slow to close so there's a slight overshoot – too many K+ diffuse out
5. Resting potential: Restored by Na+/K+ pump