a degeneration of blood vessels caused by the accumulation of fat deposits in the inner wall, a group of disorders that cause the blood vessels to thicken, harden, and lose their elasticity. Arteriosclerosis is caused by an excess amount of fat in blood vessels that join together and stick to the walls of the arteries. This narrowing of the vessels leads to high blood pressure. Blood clots can form, blocking the artery, and cutting off blood flow. If this happens in the heart, this results in a heart attack.