1. AP arrives at presynaptic neurone
2. Ca+ channels open and Ca+ enters knob
3. triggers vesicles with NT inside to fuse w presynaptic mem
4. acetycholine released into cleft
5. NT fuse w receptors on Na+ channels so they open and Na+ diffuses in
6. influx generates new AP in postsynaptic
7. acetylcholine esterase splits NT back into Cl- and ethanoic acud and they diffuse back
6. ATP released by mitochondria to recombine acetycholine stored back in vesicles
7. Na+ channels close again