● Vomiting appears effortless and is not projectile.
● Irritable child with periods of apnea.
● Acidic gastric secretions of pH < 7.0 into esophagus.
● In adolescents, heartburn 30 to 60 minutes after meals.
● Esophageal manometry shows less strength of esophageal sphincter.
● Fiberoptic endoscopy or esophagography with barium swallow shows involved sphincter and reflux of stomach contents into the esophagus are present. This condition may also be associated with the development of esophageal cancer later in life