DNA

• All DNA virus are ds-DNA except

  Parvovirus
• All DNA Virus are All are icosahedral except

  Poxvirus (COMPLEX)
• All DNA Virus are enveloped except

  Papovavirus, Adenovirus, Parvovirus
• All DNA Virus multiply in nucleus except

  Poxvirus (cytoplasm)
• Largest DNA virus

  Poxvirus
• Smallest DNA virus

  Parvovirus
• - Naked icosahedral: double stranded linear DNA

  - Number 1 viral conjunctivitis

  - Unusually stable to chemical or physical agents; adverse pH conditions

  - Causes upper and respiratory diseases such as

  Adenoviridae
• Adenoviridae causes

  - Pharyngitis

  - Conjunctivitis

  - Pneumonia
• Adenoviridae incubation period if

  - Gastroenteritis in children

  - Incubation period

  3-10 days and 2-14 days
• Adenoviridae MOT

  droplets, the fecal-oral route or fomites
• Adenoviridae CPE

  Grape-like cluster
• Adenoviridae has how many serotypes

  47
• (Adenoviridae serotypes)

  - Acute Respiratory Disease

  Serotype 3,4,7,21
• (Adenoviridae serotypes)

  - Pharyngitis

  Serotype 3,7
• (Adenoviridae serotypes)

  - Epidemic Keratoconjunctivitis

  Serotype 8,19
• (Adenoviridae serotypes)

  - Hemorrhagic Cystitis


  Serotypes 11,21
• (Adenoviridae serotypes)

  - Infantile Gastroenteritis


  Serotypes 40,41
• - Smallest DNA virus

  - naked - single stranded linear DNA

  - Also known as B19 Virus

  - Virus can stop production of RBC in the bone marrow

  - Aplastic crisis in patients with hemoglobinopathies and fetal infections (hydrops fetails)

  Parvoviridae
• (Parvoviridae)

  - classic childhood disease

  1. Measles (Rubeola)

  2. Scarlet Fever

  3. German Measles (Rubella)

  4. Duke's Disease (associated with S. aureus)

  5. B19 Virus

  6. Roseola infantum (Human Herpes virus 6 and 7)
• (Parvoviridae)

  - causes: Fifth Disease or Erythema Infectiosum

  
  

  B19 virus or Parvovirus B19
• (Parvoviridae)

  - B19 virus or Parvovirus B19 is characterized by

  fever and slapped cheeks
• (Parvoviridae)

  - B19 virus replicates in

  - immature erythroid cell

  - adult bone marrow

  - fetal liver
• - 2nd smallest DNA virus

  - Naked: double stranded circular supercoiled DNA

  Papovaviridae
• (Papovaviridae)

  - PAPOVA is an acronym for

  Papilloma, Polyoma, and Vacuolating Virus
• (Papovaviridae)

  - HPV that causes cervical cancer

  - most important

  Papilloma
• (Papovaviridae)

  - BK Virus

  - JC Virus

  - Causes opportunistic infections on immuno-suppressed patients

  Polyoma
• (Papovaviridae)

  - Simian Vacuolating virus

  - does not affect humans

  Vacuolating virus
• (Papovaviridae)

  - Papilloma virus

  - Causes: human warts and cervical cancer

  - 70 strains have been identified so far

  - Most prevalent viral sexually transmitted disease in the US

  Human Papilloma Virus
• (Papilloma)

  - affects the squamous epithelial tissues/cells

  - benign proliferation of the keratinized squamous epithelial resolution is within 1-2 years

  Warts or Condylomas
• (Papilloma)

  - also known as Condyloma acuminate

  Genital Warts
• (Papilloma)

  - Transforming proteins associated with initiating oncogenes

  E6 and E7
• (Papilloma)

  - Papilloma is transmitted by

  sexual contact, direct contact or with birth
• (Papilloma serotypes)

  - Plantar Warts

  HPV-1
• (Papilloma serotypes)

  - Genital Warts

  HPV-6 and 11

  HPV-41-42
• (Papilloma serotypes)

  - Epidermodysplasia verruciformis

  HPV-5 and 8
• (Papilloma serotypes)

  - Heck's Disease (Focal Epithelial Hyperplasia)

  HPV-13 and 32
• (Papilloma serotypes)

  - Cervical Cancer, Condyloma, Accuminate

  HPV-16 and 18
• (Papilloma serotypes)

  - Subset cancer of oropharynx and penile cancer in men

  HPV-16
• (Papilloma serotypes)

  - Flat Cutaneous Wart

  - Most common in children (arms, knees, and face)

  HPV 3, 10
• (Papilloma serotypes)

  - Anogenital Warts (anus)

  HPV 6, 11, 42, 43, 44, 55, and more