multicellular organisms have smaller surface area:volume compared to single-celled organisms - not enough substances can diffuse from their outside surface to supply their entire volume
2. they need some sort of exchangesurface for efficient diffusion. The exchange surface structures have to allow enough of the necessary substances to pass through
Exchange surfaces are adapted to maxmise effectiveness:
Thin membrane - substances have short distance to diffuse
large surface area - lots of a substance can diffuse at once
animals:lots of bloodvessels - to get stuff in and out of blood quickly
animals (alveoli): often ventilated - air moves in and out