High-energy compound for storing and conserving energy
Adenosine triphosphate (ATP)
Consists of adenine, ribose, and three linked phosphates
Breakdown (Hydrolysis)
1. ADP + Pi + Energy
2. ATP + H2O
Synthesis (Removal of H2O)
1. ADP + Pi + Energy
2. ATP
Enzyme ATP-ase can weaken & break last PO4 bond releasing energy & free PO4
Movement classifications
Quick movements-lasts a few seconds
Reduced speed-lasts for several minutes
Reduced intensity(50%)-lasts for several hours
Cellular energy
Depends on duration and intensity
Energy systems
ATP-PCr (Alactic Anaerobic Energy system) (10-15s)
Glycolytic (Lactic Anaerobic Energy System)(2-3 mins)
Aerobic system (>3 min)
ATP-PCr System
1. ATP breakdown (4 s)
2. Phosphocreatine (PC) breakdown (10s)
3. ADP + Pi + Energy
4. ADP + Pi + Energy
5. ADP + Pi + Energy
6. ADP + Pi + Energy
Without oxygen presence (anaerobic)
ATP breakdown
Produces adenosine diphosphate (ADP) and one single phosphate (Pi)
Phosphocreatine (PC) breakdown
Creatine + Pi
ADP and Pi rejoining
Forming more ATP
1 mole of ATP is produced per 1mole of PCr
ATP-PCr System
Lasts 10 - 15 seconds
Produce rapidly
For explosive movement , powerful activities eg. 100 m sprints, jumping, throwing, weight lifting
Recovery
1. Replenish
2. Takes 2-6 min
3. If activity continues at a high intensity these stores may only partially replenish
Training the ATP-Pcr System
Power training
Speed training: faster/same speed than used in sports
Adequate rest (at least 2 min)
'Work to rest ratio'- 1:10/12
Glycolysis
The breakdown (lysis) of glucose /glycogen, controlled by enzymes in the absence of oxygen
Glycolytic (Lactic Anaerobic)
Takes longer (slower muscle contraction)
Greater ATP production
Involved breakdown of food source
Byproduct - lactic acid , no oxygen, muscle fatigue
Lasts 2 – 3 minutes
Eg. 400 m sprint
Glucose
2ATP + 2LA (digested component of carbohydrates)
Glycogen
3ATP + 2LA (the storage form of glucose)
Steps in Glycolytic
1. Initially glucose in the blood or glycogen stores to be broken down by a series of enzymes into glucose-6-phosphates
2. Further break down to pyruvate and hydrogen ions
3. ATP are used to fuel glycolysis and 4 are created so the body gains 2 ATP to use for muscular contraction
4. This system is 'anaerobic' there isn't oxygen to break down pyruvate and synthesise anymore ATP
Nicotinamide adenine dinucleotide (NAD)
Transport hydrogens and associated electrons
Flavin adenine dinucleotide (FAD)
Transport hydrogens and associated electrons
Lactate
Formed when hydrogen ions (H+) are released into the muscle cell during glycolysis and cannot be transported to the mitochondria due to lack of oxygen
If a muscle cell becomes too acidic, muscle stops functioning as the enzymes not able to function
Lactate is removed from the muscle cell to enable exercise to be continued for a little longer
Lactate that is removed from the muscle is carried to surrounding muscles that have oxygen available and also to the liver where it is converted back to pyruvate and or glucose for further glycolysis and energy production via the aerobic energy system (Cori Cycle)
Training the Glycolytic System
Aim to increase tolerance to lactate, the removal of lactate and improving the rate at which glycolysis produces ATP
For full recovery : ratio of 1:6 (6 seconds of rest for every second of work)
A ratio of 1:3 - to greater lactate response (some fatigue carried into the next set)
This helps to condition the body to clear (get rid of) lactate
1:1 or 2:1 ratio – lactate tolerance
Glycolytic processes
Glycolysis—Breakdown of glucose; may be anaerobic or aerobic
Glycogenesis—Process by which glycogen is synthesized from glucose to be stored in the liver
Glycogenolysis—Process by which glycogen is broken into glucose-1-phosphate to be used by muscles
Gluconeogenesis- Formation of glucose from non carbohydrate source (liver)
The liver
1. Goes through various chemical reactions
2. Convert it back to pyruvate and or glucose for further glycolysis and energy production via the aerobic energy system (Cori Cycle)
Training the Glycolytic System
Aim to increase tolerance to lactate, the removal of lactate and improving the rate at which glycolysis produces ATP
For full recovery : ratio of 1:6 (6 seconds of rest for every second of work)
A ratio of 1:3 - to greater lactate response (some fatigue carried into the next set)
This helps to condition the body to clear (get rid of) lactate
1:1 or 2:1 ratio – lactate tolerance
Glycolysis
Breakdown of glucose; may be anaerobic or aerobic
Glycogenesis
Process by which glycogen is synthesized from glucose to be stored in the liver
Glycogenolysis
Process by which glycogen is broken into glucose-1-phosphate to be used by muscles
Gluconeogenesis
Formation of glucose from non carbohydrate source (liver)
Oxidative System
Relies on oxygen to breakdown fuels for energy
Produces ATP in mitochondria of cells
Yield much more energy (ATP) than anaerobic systems
Working sub-maximally at 60 – 80% of maximum effort
Involved in endurance events
Involved in aerobic glycolysis and fat oxidation
Oxidative System
1. Aerobic glycolysis
2. Krebs cycle
3. Electron transport chain
Acetyl CoA
Pyruvate from glycolysis is converted to acetyl coenzyme A by removing CO2, H+, NAD+, FAD
Krebs Cycle
Two carbons enter in the acetyl fragment of Acetyl CoA
Produces CO2
Coenzymes are reduced: 3 NADH and 1FADH2 are produced
One ATP molecule is produced by substrate level phosphorylation
Oxaloacetic acid is regenerated
For every glucose molecule split during glycolysis, two acetyl fragments are produced. Thus, it takes 2 turns of the cycle to complete the oxidation of glucose
6 NADH and 2 FADH2 (per glucose) carry high energy electrons to the electron transport chain where ATP is produced by chemiosmosis
Most of the ATP output of respiration results from this oxidative phosphorylation